Anatomy and Roles of the
The uterus, also known
as womb, is an organ of the female
reproductive system located in the lower abdomen. It is a pear-shaped hollow muscular organ whose the
interior is highly
vascularized. It is the nest for the reception of the embryo and the development of the fetus. It has 3
layers; and connected to the
fallopian tubes, the cervix and the vagina.
The inner lining of the
wall, the endometrium, is sensitive to estrogens, which are female sex hormones. During menstrual cycle, the
thickness of the endometrium increases to promote the establishment of the future embryo. The cervix
is closed by a thick mucus
which becomes thin and permeable to sperm only at the time of ovulation. If fertilization does not occur, the
endometrium eventually destroyed, and becomes part of the menstruation.
Conversely, if fertilization occurs, the egg migrates from the ovaries through the fallopian tubes to ultimately
stay in the uterus. As the fetus develops, the uterus extends up to 35 cm to facilitate the development of the
placenta and the fetus. During childbirth (labor), the uterus undergoes
muscle contractions in order to expel the newborn through the vagina.
Uterine Sarcoma (Cancer
of the Uterus)
sarcoma is a very rare type of
cancer in women. It is a condition in which malignant cells develop and reproduce in the muscles of the
uterus or tissues that hold it. About 95% of these tumors are endometrial cancers; they develop in the inner
lining of the uterus.
In terms general, there are three types of uterine sarcomas:
carcinosarcoma(formerly called malignant mixed Müllerian
develops in the endometrium; it is the most common of the three types.
which developsin the muscular wall of the uterus (myometrium);
it is the second most common of uterine cancer.