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83) SPRYCEL (Dasatinib)
Brand name: Sprycel®
Generic name: Dasatinib Therapeutic Class: protein-tyrosine kinase inhibitorsManufacturer / Distributor: Bristol-Myers Squibb Availability: Sprycel is available by prescription only FDA Approval: The U.S. Food and Drug Administration (FDA) approved Sprycel in 2006 for the treatment of certain types of cancers (see indications) Indications: Sprycel is used to treat the following cancerous conditions:
Sprycel is sometimes used to treat other medical conditions not mentioned in this article; talk to your physician or pharmacist for more information. Dosage form: Sprycel is available in tablet form to be taken by mouth Dosage: to choose the most effective dosage to combat the disease, your physician will rely on several factors: age, health status, body surface area (BSA), type and severity of the cancer. Usually, lower doses are given to patients that are taking other drugs. Misusing Sprycel can cause serious health problems; it should be prescribed by an oncologist or physician trained or experienced in the use of chemotherapy drugs. Do not change or stop taking the medication even if you experience side effects; chemotherapy drugs – including Sprycel - cause side effects in most patients. Usually, Sprycel is taken 2 times daily, 1 tablet in the morning and 1 tablet in the evening, with or without food. It is better to take the medicine around the same times every day. SPRYCEL should be swallow whole, do not chew or crush the tablet. In addition, avoid drinking grapefruit juice or eating foods rich in fat during the therapy. Taking Sprycel exactly as directed by your doctor is very important. If for valid reasons (such as development of major complications) you cannot continue the therapy, contact your physician immediately; do not discontinue the treatment without first contacting your doctor. Storage: keep Sprycel tightly closed in the container it came, out of the reach of children. Store Sprycel at room temperature (15-25 ° C), away from heat above 40 ° C, light and moisture. Sprycel and all other medications should not be used beyond the expiration date printed on the container. Overdose: any chemotherapy drug overdose can be fatal. The risk of complication is even higher when the drug is overdosed for a long term. In fact, overdosing of certain chemotherapy drugs, including Sprycel, can lead to death. Even in the absence of overdose, Sprycel can damage the bone marrow. It is extremely important that you take the medication as indicated by your health care provider or according to the directions on the label. Missing dose: do your best to take the medication around the same time every day. In case you forget to take a dose, take the missed one as soon as you remember it. However, if it is almost time for your next dose, do not double the next dose to recover the missed one. Contact your doctor or wait to go back to your regular schedule. Contraindication : Sprycel is contraindicated in case of:
Mechanism of action (MOA): Sprycel is a protein-tyrosine kinase inhibitor. That is, it works by blocking the protein kinases, proteins that are located within the leukemic cells, and are responsible for their uncontrolled proliferation. Interactions: if you are taking sprycel, it is better to talk to your doctor before taking aspirin, vitamins, nutritional supplements, or St. John's wort. Certain substances can interact with sprycel, et cause health problems. Common drugs that tend to produce interaction with sprycel include:
Side effects: In addition to attacking cancer cells, Sprycel may interfere with certain normal cells, and lead to the development of side effects in some patients; most common Sprycel side effects include:
If the side effects above persist for weeks, contact your oncologist. In addition, contact your doctor if you experience any of these symptoms:
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