Warning: Using Sorafenib puts patients are an elevated risk for heart
problems such as ischemia and heart attack (infarction). Hemorrhage and high blood pressure (hypertension) are also common risks. The most frequently reported side
effects affect the skin of the feet and hands. Blistering, oozing, and rashes are frequently observed. Severe
pain experienced on the soles of the feet and palms of the hands has also been reported. Other side effects include easy
bleeding and bruising, nausea, sweating, feeling short of breath, rapid weight gain, and loss of
for use during pregnancy, this drug can cause birth defects and/or fetal loss. Nursing mothers should avoid the
use of this drug, and those using this drug should be on birth control prior to and during treatment, as well as
at least two weeks after the cessation of treatment.
Nexavar is an anti-cancer
drug and Sorafenib is a generic name under which this drug is administered. It is indicated for the treatment of
specific liver and kidney cancers. It is intended for use in the treatment of inoperable hepatocellular carncinoma
and advanced renal cell carcinoma.
interfering with cell growth in these forms of cancer, serafenib slows the spread of liver and kidney cancer
cells through the body.
This drug comes in
tablet form and is intended for oral use. The prescribed daily dose is 400 mg per day. This total daily dose
is to be taken in two divided doses of 200 mg each. For highest bioavailability, this drug should be taken on
an empty stomach, with water, at least an hour prior or two hours after food ingestion.
doses should be taken as soon as they are remembered, unless it is nearly time for the next dose. More than one
dose should never be taken at any given time, despite the missing of previous doses. If it is suspected that
multiple doses have been ingested at one time, medical attention should be sought.
Overdose: Sorafenib overdose can be dangerous if
taken for a long term. Chemotherapy drugs, including Sorafenib, tend to lead to a decrease in white blood cells
and platelets which puts you at risk of serious infections. Follow the directions on the prescription label, or
talk to your physician or pharmacist if you don’t understand the indication. Sorafenib is a strong medication;
take it as prescribed.
Missing dose: It is
very important to take the medication around the same time every
In case you forget to take a dose, take the missed
one as soon as you remember it. However, if it is time for your next dose,
do not double the next dose to recover the missed one; it can be dangerous. Contact your doctor or wait to go back
to your regular schedule.
store Sorafenib at room
temperature, away from direct sunlight, moisture and heat. Keep Sorafenib and all medications out of the
reach of children. Do not store Sorafenib in the bathroom. Sorafenib and
all other medications should not be used beyond the expiration date printed on the container.
Patients who have a history of allergic reaction to Nexavar should not take Sorafenib. Patients suffering from
squamous cell lung cancer should not take this drug concurrently with carboplatin and
Mechanism of action (MOA): Sorafenib is a multikinase inhibitor;
by its antiangiogenic action, it slows or stops the growth of cancerous cells, and delay the growth of new blood
vessels that feed cancer cells.
Interactions: Serafenib bioavailability was inhibited by concurrent use with other CYP3A4
activity inducers. Examples of CYP3A4 activity inducers include phenobarbital, rifabutin, carbamazepine, St. John's
wort, rifampin, phenytoin, dexamethasone, rifabutin, and rifampin. Coumadin also affected the absorption of this
Concurrent use of neomycin also
significantly impacted the absorption of Sorafenib in patients. The affect on absorption with the use of other
antibiotics has not been adequately researched.
In general, Tell your doctor or pharmacist if you are taking or planning to take any of these
- Warfarin (Coumadin)
- Bupropion (Wellbutrin,
- Carbamazepine (Equetro,
- Cyclophosphamide (Cytoxan,
- Doxorubicin (Doxil,
- Efavirenz (Sustiva)
- Irinotecan (Camptosar)
- Methadone (Dolophine,
- Phenytoin (Dilantin,
- Rifampin (Rifadin,
Side effects: Sorafenib not only attacks cancer cells but
cells, which often leads, in most patients, to the following side effects:
- nausea and
- ulcers in the mouth
- reduced urine
If the side
effects above persist for weeks, contact your oncologist. In addition, contact your doctor immediately if you
experience any of these symptoms:
- bluish discoloration
whites of the
yellowing of eyes or skin
- black, tarry stools
shortness of breath
abnormal or accelerated heartbeat
blood in urine or stool
fever associated with chills
pain in lower back or side
pain or difficulty when passing urine
swelling of feet and lower legs
Unusual bleeding or bruising
Approves Sorafenib for Patients with Inoperable Liver Cancer