Warning: A warning has been issued by the Federal Drug Administration
regarding the risk of arterial hypertension within the lungs of patients taking Sprycel. This pulmonary arterial hypertension can have harmful effects on heart function. The heart’s
ability to adequately supply blood to the lungs can be adversely impacted with the use of this medication.
Swelling, fatigue, and shortness of breath are all signs of pulmonary arterial hypertension. Incidence of such
symptoms should be reported to a medical professional immediately.
A tyrosine kinase inhibitor, this medication is indicated for the treatment of acute lymphoblastic leukemia as well
as chronic myeloid leukemia. Leukemia causes abnormal protein production, which results in abnormal chromosome
development. Consequently, these abnormal chromosomes result in unlimited multiplication of white blood cells. This
medication blocks the action of this abnormal protein and therefore halts the indefinite multiplication of
cancerous cells as well as tumor growth.
also be used to treat metastatic melanoma and other
medical conditions not mentioned in this article; talk to your physician or pharmacist for more
Dosage: Sprycel is available in tablet form to
be taken by mouth. It is recommended that chronic myeloid leukemia be treated with 100 mg, to be taken by mouth
once daily, in the chronic phase. For treatment of accelerated phase chronic myeloid leukemia, 140 mg of this
medication should be ingested by mouth, once daily. Tablets are to be taken whole, with or without food. Tablets
should never be bitten, broken, or crushed. The dosage may be escalated to 180 mg per day should cytogenetic or
hematologic response not be successful.
doses should be taken as soon as remembered unless it is nearly time for the following dose. In this case, only
the present dose should be ingested. Multiple doses are never to be taken to make up for missed
Overdose: any chemotherapy drug overdose can be
fatal. The risk of complication is even higher when the drug is overdosed for a long term. In fact, overdosing
of certain chemotherapy drugs, including
Sprycel, can lead to
death. Even in the absence of overdose,
Sprycel can damage the
bone marrow. It is extremely important that you take the medication as indicated by your health care provider or
according to the directions on the label.
Missing dose: patients
shopuld do their best to take the medication around the same
time every day.
In case you forget to
take a dose, take the missed one as soon as you remember it. However, if it is almost time for your next
do not double the next dose to recover the missed one. Contact your doctor or wait to go back to your regular
keep Sprycel tightly closed
in the container it came, out of the reach of
Sprycel at room temperature (15-25 ° C), away from heat above 40 ° C, light and moisture. Sprycel and all other
medications should not be used beyond the expiration date printed on the container.
is contraindicated in case of:
to the drug or any of the constituents
Etravirine, Carbamazepine, and Oxcarbazepine are examples of strong CYP3A4 inducers that may reduce plasma
concentrations of this medication. Nefazodone, Amprenavir, and Ritonavir are examples of CYP3A4 inhibitors which
can exaggerate plasma concentrations of this medication. As a result, the use of such medications is best
avoided during treatment with Sprycel.
Medications which reduce stomach acid
should also not be taken concurrently with this medication. While medications used to neutralize stomach acid
may be used, they must not be taken within two hours before or after ingestion of this drug.
thinners such as Warfarin and non-steroidal anti-inflammatory drugs such as naproxen should not be taken while a
patient is being treated with Sprycel. Seizure medications and live vaccinations should also be avoided during
In addition to attacking cancer cells, Sprycel
may interfere with certain normal cells, and lead to the development of side effects in some patients; most common
side effects include:
loss of appetite
joint pain or pain in your hands or the feet
nausea and vomiting
Stomach pain or swelling
mouth sores or swelling and pain inside your mouth
the side effects above persist for weeks, contact your oncologist. In addition, contact your doctor if you
experience any of these symptoms:
signs of infections: fever, sore throat, chills...
sudden severe headache
sudden weight gain
shortness of breath or difficulty breathing
coughing up bloody mucus
persistent chest pain or chest pressure
rapid or irregular heartbeat
unusual bruising or bleeding
black and tarry stools
blood in stools or urine
slow or difficult speech
Weakness or numbness of an arm or leg
swelling of the eyes, hands, arms, feet, ankles or lower legs