Warning: This drug may cause severe kidney problems, severe allergic
reactions, and bleeding problems. Platinol may also decrease your body’s ability to fight infection (bone marrow
suppression), cause hearing problems (more common in children), and severe nausea and vomiting in some cases.
your doctor immediately if you suffer from any of these symptoms: change in the amount of urine, rash, fast
heartbeat, trouble breathing, swelling of the face, ringing in the ears, dizziness, hearing loss, easy bruising
or bleeding, signs of an infection (e.g. fever and persistent sore throat), unusual tiredness and weakness, and
nausea and vomiting.
Indications: This treatment is for certain types of
cancer. It is a chemotherapy drug that you can either use alone or with other medications to slow and/or stop
the growth of cancer.
used, most of the
times, in association with other anticancer drugs, to treat the following
- multiple myeloma
- testicular cancer
- ovarian cancer
- bladder cancer
and neck cancer
- esophageal cancer
small cell lung
- cervical cancer
- stomach cancer
- Prostate cancer
- Hodgkin's lymphoma
- non-Hodgkin’s lymphoma
can be used in the treatment of other medical conditions not mentioned in this article; talk to your doctor or
pharmacist for more information.
Dosage: This medication is given intravenously
by a medical professional. Your dosage will depend upon your weight, medical condition and response to therapy.
Platinol should not be given more than once every 3 to 4 weeks.
you are taking this medication you should drink plenty of fluids to avoid kidney related side effects. Your
doctor should prescribe you intravenous fluids to take while receiving treatment. Ask your doctor how much fluid
you should be taking in.
Platinol overdose leads mainly to kidney failure and bone marrow depression - a condition in which
the bone marrow is
unable to produce normal amounts of red blood cells (RBCs), white blood cells (WBCs) and
In addition, overdosing the medication can cause liver failure, deafness, eye problems (retinal detachment),
intractable vomiting (the fact that you are unable to stop the
, neuritis (inflammation of a nerve or a portion of
the nervous system)
, and even death. If you think you've been given an overdose of Platinol, contact immediately your doctor or the
poison control center nearest you.
Tell your doctor of all allergies you know you have, as you may be allergic to some of the ingredients in this
You should avoid people that have
recently had the oral polio vaccination, and avoid having immunizations yourself.
Certain people that have some medical
conditions should not use Platinol, such as kidney disease, decreased bone marrow function (e.g. anemia,
leukopenia), and hearing problems.
Tell your doctor of your entire
medical history, including mineral imbalance (low levels of calcium, phosphate, sodium, magnesium and
potassium), numbness/tingling of the hands and feet, gout, and kidney stones.
Caution should be used when this
treatment is used for children, as they may be more susceptible to the side effects, including hearing
Caution should be advised when using
this drug in the elderly, as they are more susceptible to the side effects, including kidney problems,
numbness/tingling of the hands and feet, infections and bleeding problems.
Mechanism of action (MOA):
Platinol selectively inhibits the synthesis of DNA, and thus slows or stops the growth of cancer cells in the
Your doctor and pharmacist should already be aware of all the possible interactions. You should notify them of
all medications you are taking, as well as nonprescription and herbal.
There are some medications that are
known to cause interactions with Platinol, such as aminoglycoside antibiotics (e.g. gentamicin, neomycin),
amphotericin B, anti-seizure medications, (e.g. phenytoin), diuretics (e.g. furosemide, ethacrynic acid,
bumetanide), nalidixic acid, pyridoxine when used in combination with both altretamine and
Platinol also damage non-cancerous cells, which causes various side effects in most patients. The most common
Platinol side effects include:
- diarrhea or
- nausea and
- changes in
- Numbness or tingling
in the fingertips and toes.
cause serious side effects which require immediate medical attention; contact your doctor immediately if you
experience any of these symptoms:
- shortness of
- unusual bruising or
- dizziness or/and
- pain in your side or
- Swelling of your feet
ch.oddb.org, Information professionelle sur Platinol-Teva®
2 - nlm.nih.gov, Platinol