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Paraplatin ( Carboplatin)

 

Warning: The use of Paraplatin may result in decreased blood cells in the bone marrow. Serious blood disorders may occur because of the use of this medication resulting in the increased possibility of infections and bleeding trouble.

 

There is a rare possibility of an allergic reaction with serious consequences. If you experience symptoms such as uncommon fatigue, an irritating rash, swelling, dizziness, or symptoms of an infection, contact your doctor without delay.

 

Indication:  Paraplatin is a brand name of the drug carboplatin and is part of the family of drugs known as platinum-containing compounds. These drugs prevent or slow the development and spread of cancer cells. Paraplatin is used in the treatment of ovarian carcinoma, or cancer of the ovary. In some cases, Paraplatin may be used to treat other types of cancer in the lungs, head and neck, or bladder. The medication may be used to treat certain types of tumors. Contact your doctor to determine if this medication is right for your condition.

 

The medication can also be used to treat the following cancers:  

 

  • testicular cancer 
  • Retinoblastoma.  

Dosage:  This medication is injected intravenously for over fifteen or sixty minutes. The precise dosage will be determined by your physician and will be determined by the type of cancer you have and how well you respond to the treatment. The dosage and the length of time you receive these treatments may also be affected by other medications you are currently taking and your body size.

Overdose: Overdosing Paraplatin increases the toxic effects of the medication, and cause severe headaches, malaise or life threatening conditions. If you suspect that you are overdosed, contact your health care provider or visit a drug and poison center  near immediately. Any negligence in chemotherapy overdose can lead to death.  

Contraindications: While taking carboplatin may interfere with the ability to become pregnant or to produce sperm, take precautions to prevent pregnancy as this drug may harm the fetus. Do not nurse your infant while using carboplatin. If you are pregnant or may become pregnant, discuss the use of the medication with your doctor immediately.

 

Tell your doctor if you have a history of kidney problems or if you have ever used, or are using, any other platinum-containing compounds.  Discuss with your doctor the risks that may occur when using a regimen of chemotherapy medications.

 

Paraplatin  is not indicated for patients who have any of these conditions:  

  • allergy to Paraplatin or its ingredients   
  • liver failure   
  • significant reduction of the function of the bone marrow 
  • bleeding tumor   
  • History of severe allergy to mannitol.     

Interactions: Carboplatin may interact with other medications, especially aspirin. Do not receive any vaccinations while using this medication without consulting with your doctor first. This includes yearly vaccinations like flu shots. Some medications that could interfere with the effectiveness of this medication include certain antibiotics, some anti-seizure medicines and diuretics.

As with all medications, there could be side effects and unwanted interactions between this medication and other drugs. Always provide your doctor with information about all of the prescription or non-prescription drugs that you are currently taking. If you are taking vitamin or herbal supplements, inform your doctor of those as well.

 

 Talk to your health care provider if you are taking or planing to take any of the following medicines: 

  • vaccins   
  • Ganciclovir  , an antiviral drug  
  • Amphotericin B, a polyene antifungal drug  
  • Azathioprine  , an immune system inhibitor  
  • Digoxin, a medication used in the treatment of several heart conditions 
  • Plicamycin  , a chemotherapy used to stop the growth of cancer cells 
  • Amiodarone  , a medication used to treat irregular heart beat 
  • Barbiturates,  depressant drug that causes relaxation and sleepiness 
  • Cimetidine  , a drug used to inhibit the production of acid in the stomach 
  • Colchicines  , a medication used to treat pain of gouty arthritis 
  • Cyclophosphamide  (Cytoxan), a medication of the alkylating agent family used to treat a variety of cancers  

Side effects: In addition to stopping the growth of cancer cells, Paraplatin may also interfere with your healthy cells that multiply quickly, and cause adverse effects. Common Paraplatin side effects include: 

  • fatigue
  • sleepiness
  • hair loss
  • weight loss
  • ear ringing or hearing loss
  • nausea and vomiting
  • decreased appetite
  • taste changes
  • vision changes
  • numbness or tingling in the fingertips
  • bowel disorders (constipation or diarrhea)
  • Formation of sores in the mouth

Although rare, Carboplatine can cause serious side effects which require immediate medical attention; contact your doctor immediately if you experience any of these symptoms:  

  • dizziness  
  • fainting (temporary loss of consciousness) 
  • shortness of breath or difficulty breathing 
  • painful or difficulty swallowing 
  • yellowing of the skin or eyes (jaundice) 
  • unusual bruising or bleeding 
  • skin disorders such as rash, hives or itching 
  • Swelling of your arms, feet, ankles, or lower legs. 

 

References:  

 

1 - nlm.nih.gov,   Carboplatin