Melphalan can cause blood disorders and may lower your white blood cell counts and contribute to anemia by
affecting your bone marrow function. Improper or deficient bone marrow function can result in a decreased ability
to fight off infections and sicknesses and may result in an increased risk of bleeding.
Melphalan may increase your risk of
developing certain cancers such as leukemia and carcinoma.
Melphalan may cause birth defects and
should not be taken if you are pregnant or breastfeeding or if you plan on becoming pregnant. Precautions should
be taken so that you do not become pregnant while taking this medication.
Melphalan belongs to a class of drugs
known as alkylating agents and works by interfering with the growth and spread of various cancer cells
throughout the body. This medication is used for different types of cancer, including (but not limited to)
multiple myeloma (blood cancer), breast cancer, and ovarian cancer. Some minor side effects of this medication
may include nausea, vomiting, diarrhea, itchy skin and skin rash, sores or white patches on the inside of your
lips or nose, and temporary hair loss. If you experience these side effects or more severe side effects, notify
medication should be taken orally and is normally taken with a large glass of water, but your doctor may give
you instructions to take Melphalan on an empty stomach. Your doctor will give you specific instructions
regarding dosage amounts and these instructions should be followed very carefully. Your doctor will administer
dosage instructions based on your current health condition, your blood cell count, and your response to
treatments. Your doctor might even change your dosage instructions at various times based on how you are
responding to treatment, so it is very important that you follow your doctor’s instructions carefully to get the
best results from this medication and to avoid adverse reactions. Melphalan tablets should be stored in your
refrigerator and away from excess light.
Mechanism of Action
Melphalan damages cancer cells by forming cross-linkages between DNA strands (deoxyribonucleic acid), which
thereby inhibiting the replication of tumor cells.
Contraindications: Do not take Melphalan without consulting with
your physician if you are allergic to Melphalan, Chlorambucil, or any components of the Melphalan
The medication is not recommended in the following conditions:
- breastfeeding is not recommended
while taking Alkeran
- using Melphalan is
not recommended during pregnancy, especially during the first quarter; the drug may cause problems which
can be harmful to the fetus
- Elderly, infants and children are
treated with Melphalan under strict medical supervision.
have one of the following medical conditions, it is important to report them to your health care provider before
beginning an Melphalan treatment:
- glucose-galactose malabsorption
- You have
been treated with radiotherapy or antineoplastic agents during the previous 3 weeks.
To avoid negative drug
interactions, you should inform your doctor if you are taking any treatments or medications that affect your
immune system, such as radiation therapy, cyclosporine, chemotherapy, and any other medications that you are
currently taking. There are many drugs that may interact with Melphalan, so it is important that you inform
your doctor of all medications that you are currently taking or that you plan on taking.
: Melphalan attack not only cancer cells but healthy cells that multiply quickly, which often leads to adverse
effects. The most common Melphalan side effects include:
loss of appetite
loss of weight
nausea and vomiting
- increased risk of
- Pulmonary fibrosis
blistering, sometimes inflammation of the mouth
doctor immediately if you experience any of the following symptoms:
green, black, tarry stools
red urine or blood in
missed menstrual periods
sudden low or high blood pressure
yellowing of the skin or eyes
- increased risk of infection
Difficulty breathing or shortness of breath
- severe clinical depression symptoms