Warning: Patients must be wary of side effects and respond appropriately
and quickly. If any of the following symptoms occur, get emergency
help right away: trouble breathing, hives, or swelling of face, lips, throat, or tongue. Contact your physician immediately with any of these serious side effects: high
blood sugar (increased thirst or increased urination), nausea or vomiting, a sudden numbness or weakness, chest
pain or a sudden cough, or high blood pressure (severe headache or buzzing in the ears).
Megace is a manufactured drug designed to simulate the female hormone progesterone. This drug helps in treating some of the symptoms associated with acquired
immunodeficiency syndrome (AIDS) including loss of appetite and weight loss. It has also proven effective in the treatment of endometrial cancer and advanced
breast cancer. Megace is used
to treat certain forms of prostate
is also used to treat malnutrition, loss of appetite and weight loss in patients with AIDS. That is, by using
Megace, you can have your appetite and weight increased.
Megace comes as a tablet, a suspension (liquid) and a concentrated suspension (called Megace ES) to take by
Patients drink the liquid after shaking it
thoroughly. It is important for a patient to take this drug exactly according to the instructions of the health
care provider. The measurements of the dosage need to be exact.
Patients must measure the liquid with a special medicine cup or dose-measuring spoon. Do not use a regular table spoon – this is not sufficiently
accurate. Special measuring spoons are available from your local
treatment you have surgery, become ill, develop a situation that causes high stress, or get an infection, your
dosage requirements may change. Be sure to contact your physician
in any of these situations to find the correct dosage. Do not
change the dosage or treatment schedule on your own.
should be stored at room temperature, and away from any sources of moisture and heat.
Storage: store Megace at room temperature, away
from direct sunlight, moisture and heat above 40 ° C. Keep Megace out of the reach of children. Do not store Megace and all medications in the bathroom. Megace and all other medications
should not be used beyond the expiration date printed on the container.
Overdose: Do not take Megace more often than
prescribed by your doctor. As with any drug, persistent overdose can be dangerous. If you think you have taken
an overdose of Megace, contact your doctor or a poison control center near you as soon as possible.
do your best to take
Megace as indicated by your doctor or pharmacist.
In case you forget to
take a dose, take the missed one as soon as you remember it. However, if it is almost time for your next
do not double the next dose to recover the missed one; it can be dangerous. Contact your doctor or wait to go back
to your regular schedule.
This medication is contraindicated for women who are pregnant. It
is rated as FDA pregnancy category X, meaning it can harm the unborn fetus as well as cause birth
defects. It is important to inform you physician immediately if you
become pregnant during treatment. For these reasons, it is
important to use a reliable contraceptive while taking this drug.
Patients are also advised to not breast-feed during treatment, although it has not been proven with certainty
that megestrol can be passed to a nursing infant, or that it is harmful to a baby.
doctor is you have a history of stroke, diabetes, kidney or liver disease, and blood clot.
Mechanism of action (MOA): Megace works by slowing or
stopping the multiplication of cancer cells in the prostate by inhibiting the production of testosterone in the
body. In the treatment of breast or endometrial cancer, Megace interfering with other hormones and proteins
necessary for the division of the cancer cells.
Interactions: It is important to tell your physician about any
drugs you are currently taking in order to avoid dangerous interactions. This is not restricted to prescription drugs, but includes over-the-counter
medications, vitamins, and herbal products. For Megace, patients
who are taking indinavir (Crixivan), insulin, or oral diabetes medications should take special
Side effects: in certain
patients, Megace can lead to
- high blood pressure
or unusual weight gain
- gas or
- erectile dysfunction or decreased sexual desire
- unexpected vaginal
tenderness or pain
- Appearance of brown spots on exposed
If the side
effects above persist for weeks, contact your oncologist. In addition, contact your doctor if you experience any
of these symptoms:
- anxiety or nervousness
- slow speech
or irregular heartbeat
- excessive sweating, mainly at
- purple, blue, or black discoloration
of the skin
- extreme hunger
pain or cramps
- difficulty breathing
pain or heaviness in chest
- weakness or numbness of an arm or
or swelling in the abdomen
Swelling of face, ankles or feet