Leuprolide (Eligard TM, Lupron®, Lupron Depot®, ViadurTM)
There are many benefits to taking this drug; however, Leuprolide is not
recommended in patients with hypersensitivity to GnRH, GnRH agonist analogs or any of the components of
ELIGARD. The medication is not recommended either in in women. The drug can cause fetal harm when
administered to a pregnant woman; spontaneous abortion may occur.
rare, isolated cases of ureteral obstruction and spinal cord compression have been observed in patients treated
with Leuprolide. This can contribute to paralysis with or without fatal complications.
This drug is for the
treatment of prostate cancer. It is not a cure. Testosterone is a hormone the body makes that is needed for cancer
to grow and spread throughout the body. This medication works by slowing the production of testosterone the body
makes, therefore slowing or stopping cancer cell growth. You can also suffer less from painful/difficult urination
while taking this treatment.
medication can also be used for other diseases or disorders, but should only be done so with a prescription from
your doctor. It can be used for disorders of the uterus in women (endometriosis, fibroids). It has also been
known to help children that are having an early puberty.
There are many ways that your doctor may prescribe you to take Leuprolide. You may take it intramuscularly or
subcutaneously. You may inject it yourself, or have a medical professional do it for you. Read all instructions
your doctor gives you before attempting to treat yourself. Your dosage and method of treatment will depend on your
response to therapy, weight and body size.
Your oncologist may do an implant under your
skin to inject the drug. If so, keep the area where you received the implant clean and dry for 24 hours; therefore,
swimming and/or bathing is not recommended during 24 hours after an Leuprolide injection. You may also need to
cover the area with a bandage until the wound heals.
The vials or kits of
Leuprolide should be refrigerated at a temperature between 2 ° C and 8 ° C, and protected from light. Do not
let the drug at the children reach. After opening, powder and solvent for the solution must be reconstituted
and administered immediately. The physicochemical stability of the reconstituted solution last about 30
minutes at 25 ° C.
Leuprolide overdose is
very rare, in fact, no cases of misuse or overdose has been reported in clinical practice. However, if
overdose occurs, medical attention is very important. In some cases, symptomatic treatment can be
Missing dose: It is
important to take medication on time as recommended by your health care provider. If for some reasons you forget a dose or
cannot be present at the hospital for the treatment, contact your oncologist before the date of the appointment.
In fact, this case is rarely reported.
Tell your doctor and any medical professional you are working with about all your allergies. You may be allergic
to some ingredients in this medication, such as the preservative benzyl alcohol, that will cause an allergic
reaction. Consult with your doctor before taking any medication.
have been known to be at a greater risk for osteoporosis (weakening of the bones) after taking Leuprolide for a
prolonged period of time. If you have osteoporosis, tell your doctor before starting this drug. If you are
taking any medications that may increase your risk for osteoporosis, such as corticosteroids (prednisone) or
anti-seizure medications (phenytoin), tell your doctor before taking this medication.
become dizzy while taking this drug. You shouldn’t do anything that will require you to be alert, such as
driving or operating machinery while on this medication. Avoid alcohol consumption.
Mechanism of action (MOA): gonadotropes are a group of cells that the body produces. They produce certain
homones such as gonadotropins follicle-stimulating hormone (FSH) and luteinizing hormone (LH). FSH and LH
are controlled by gonadotropin-releasing hormone (GnRH), another hormone produced and controlled by the
hypothalamus. Certain cancer cells such as those of prostate and breast cancers need those hormones to survive.
Leuprolide works by inhibiting
the secretion of gonadotropes.
Interactions: Your pharmacist and doctor should be aware of all
the possible interactions you may have with this drug. You should always keep a list of all medications you are
taking to avoid possible interactions.
Talk to your doctor about all prescription and nonprescription medications you are
taking; the list include but not limited to aspirin, vitamins or food supplements, and the following dugs:
(Neoral, Restasis, Sandimmune)
Side effects: attacking cancer cells,Leuprolide
normal (healthy) cells, which lead to, in certain patients, the following side
nausea and vomiting
disorder (diarrhea or constipation)
- anxiety or nervousness
and concentration problems
sensitivity of skin to sunlight
tingling in the hands or feet
- increased need to urinate,
especially at night
tenderness or change in breast size (both men and women)
- incapacity or decrease in sexual
desire in men and women
- decrease in size of
- vaginal discharge, dryness, or
- absence of menstrual periods
- Firmness or hardness at subcutaneous
drying or darkening of the skin or nails
If the side
effects above become severe or persist for weeks, contact your oncologist. In addition, contact your doctor
immediately if you experience any of these symptoms:
- fever and
- testicular or prostate
- inability to move arms
- painful or difficult
urination or red urine
bruising or bleeding
of the feet or legs
- numbness, tingling,
weakness, or pain in the feet or lower legs
of the skin or eyes.
1 - vidalpro.net, LEUPROLIDE ® 45 mg –
4 - Ganong, William F.: "Review of Medical Physiology", page 248. Lange, 2005