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Flutamide (Eulexin)   

 

Warning:  Flutamide can effect the liver seriously and can even be life threatening.  Notifying your doctor of any liver diseases you have or have had is extremely important.  It is also important to notify your physician if you notice any vomiting, dark urine, and nausea. Certain blood tests will be performed to check liver levels, it is very important to keep these appointments.

 

Indication:  Flutamide is used primarily to treat certain types of prostate cancer.  It is a non-steroidal antiandrogens which blocks the male hormone, androgen, to prevent the growth of new cancer cells.  It is often used in conjunction with a luteinizing hormone-releasing hormone agonist (LHRH). 

Dosage:  Flutamide comes in capsule form that should only be taken by mouth.  Generally it should be taken three times a day, at the same time each day. Do not just stop taking the medication if you feel better.  Flutamide should be kept in its original container and stored at room temperature.  Keep the medication in a dry place, and away from excessive moisture. It is very important to take the prescribed dose until your doctor discontinues it.

Keep all of your medications away from children at all times.  If an overdose does occur, contact the poison control center.  If at any point a person has become unresponsive from taking too much Flutamide, call 911 immediately.

 

Overdose:  Cases of overdose of Flutamide are almost inexistent; however, it is not impossible. As with all drugs, overdose or accidental poisoning can be fatal, especially in elderly patients. In fact, even at normal doses, Flutamide can cause serious or life-threatening liver damage. If you think you have taken a Flutamide overdose, contact your doctor or an emergency medical center as soon as possible. 

Missing dose: it is important to do  your best to take the medication as indicated by your doctor or pharmacist. If you miss a dose for less than 2 hours or so, take it right away. If it is almost time to take the dose, it is better to wait for the next dose. In any case, you should not double the dose; this can cause serious health problems. 

Contraindications:  If you are taking any sort of blood thinner, your provider needs to be made aware of this.  Notify your doctor is you have any blood diseases.  It is also important to notify your doctor if you smoke cigarettes.  Flutamide should only be taken by males, never females.  This drug has been show to cause fetal harm in pregnant women.  If you are pregnant or planning on being pregnant, contact your doctor immediately if this medication is ingested.  It is advised to speak with your doctor regarding the consumption of alcoholic beverages with this medication.  If any side effects, such as a erectile dysfunction (decrease in sexual desire), anxiety, or any swelling of any extremities (hands, feet), or any other unusual side effect does occur at any time while taking this medication it is highly recommended to notify your doctor.

Flutamide is contraindicated or should be used with precaution in the following conditions: 

  • being a woman
  • liver failure  
  • kidney failure   
  • allergy to Flutamide  or any of its ingredients  
  • liver disease associated with anterior Flutamide  
  • Talk to your doctor if you intend to father during the treatment.  

Interactions: Make sure that your prescribing physician is aware of all medications that you are allergic to.  It is very important for you doctor to know what other medications you are taking whether they are prescribed or over the counter. There are no dietary restrictions at this point in time; eat a well balanced diet.

 

Side effects:  Flutamide cause adverse effects in most patients; most common Flutamide side effects include:  

  • hair loss
  • headache
  • mouth sores
  • nausea and vomitting
  • constipation or diarrhea
  • decreased appetite
  • trouble sleeping
  • flushing ............................
  • dizziness
  • impotence or decreased sexual desire
  • swollen or tenderness of breasts
  • feeling of fullness in abdomen
  • dry mouth
  • Flu-like symptoms: runny nose, headaches, muscle or joint pain, fatigue, etc. 

It is important to contact your oncologist immediately if you experience any of these symptoms: 

  • nervousness
  • confusion
  • severe depression symptoms
  • chest pain
  • pain or tenderness in the stomach
  • fainting
  • unusual bleeding or bruising
  • yellowing of the skin or eyes
  • shortness of breath or difficulty breathing
  • persistent hoarseness or cough
  • infection signs: skin rash, sore throat, fever, etc.
  • chest tightness or wheezing
  • blackish stools or stools containing blood
  • pain in lower back or side
  • swelling of face, fingers, feet or lower legs
  • Bluish lips, fingernails, or palms Hand 
  • numbness, tingling, pain or weakness in hands, arms, legs or feet

 

 

Reference: 

1 - nlm.nih.gov, Flutamide 

2 - santecheznous.com, Novo-Flutamide