Warning: Eloxatin may cause serious, sometimes fatal allergic reactions
minutes after administering a dosage. Although rare, ELOXATIN has been associated with pulmonary fibrosis and
pulmonary toxicities which may lead to development of chest pain, hypotension, shortness of breath,
sudden constriction of the muscles in the walls of the bronchioles (bronchospasm),
disorientation and fainting. It also reported that patients experience serious
adverse reactions including life-threatening allergic reactions that typically result in a number of symptoms
including an itchy rash, throat swelling, and low blood pressure. This anaphylaxis may cause
death without an urgent treatment.
are experiencing any signs of an infection (fever, chills, nausea) tell your doctor immediately.
Indications: This medication is meant for the
treatment of advanced colon and rectal cancer. It is a chemotherapy drug that contains platinum, which works by
stopping or slowing the growth of cancer cells.
are other uses for this drug that should not be done unless prescribed from a doctor to do so. This drug may
also help with the treatment of testicular cancer.
Eloxatin comes in a liquid to be
taken by infusion into a vein. The injection is usually done in a hospital or a medical center that has
sterilization equipment available for its preparation. Eloxatin is given over a two hour period by a
healthcare professional. The treatment is usually given once every 2 weeks and is added with other
medications, such as 5-fluorouracil and leucovorin. The dosage that is prescribed depends on your response to
therapy and your body size and weight.
Before taking any medication, tell you doctor if you are allergic to anything containing platinum, especially
cispatin and carboplatin. You should also tell your doctor about all allergies you have, as you may have a
reaction to the inactive ingredients.
doctor should also be aware if you have had kidney problems, blood disorders, nerve disorders or bone-marrow
vision may also be affected while taking this treatment. Do not drive, operate machinery or anything that
requires alertness while on this medication.
medication is not recommended to use while pregnant or for someone that plans to become pregnant. It can harm an
unborn baby and cause serious birth defects. It is not yet know if it passes through breast milk, but it is not
have any immunizations while on this treatment before talking to you doctor. Avoid any contact with people that
have had recent oral polio vaccinations or inhaled through the nose flu vaccinations.
kidneys function less as you age. Eloxatin is removed by the kidneys, so older people may experience worsened
side effects, such as diarrhea, loss of water and potassium in the body, tiredness and fainting, and low white
blood cell count.
any contact sports or other vigorous activity while taking this medication, as your risk for cuts, bruises and
open sores increases.
Interactions: There have been some drugs that are reported to
cause interactions with this medication. Tell your doctor about all of the medications you are taking.
Aminoglycosides (gentamicin, amikacin), nonsteroidal anti-inflammatory drugs, nalidixic acid, cyclosporine,
amphotericin B, tacrolimus and vancomycin are all drugs that are known to cause interactions with
Side effects: Eloxatin also damages
non-cancerous cells that multiply rapidly, which lead to, in most patients, development of adverse
reactions. Common Eloxatin
- nausea and vomiting
- mouth blistering
gain or loss
- muscle, back, or joint
skin and mouth
- redness or peeling of the skin on
the hands and feet
- sweating, mostly at
- stomach pain
If the side
effects above become severe or persist for weeks, contact your oncologist. In addition, contact your doctor
immediately if you experience any of these symptoms:
and severe clinical depression
tingling and numbness in hands and feet
weakness that interferes with daily activities
of the eyes or skin
- bloody or
of feet or legs
- dark or
of anemia and / or infection:
b) cough without
mucus that persist
d) Fast or
irregular heartbeat, etc..
2 - nlm.nih.gov
3 - http://products.sanofi.us/eloxatin/eloxatin.html#S5.1