Warning: The U.S. Food and
Drug Administration (FDA) is warning the public that Sprycel (dasatinib) may increase the risk
of a rare, medical condition called pulmonary arterial hypertension (PAH). This condition is characterized by
abnormal high blood pressurein the arteries of the lungs, causing the heart to work harder to able to pump blood into the
lungs. This overworking can make theheart muscle to become weak and unable to pump enough blood through the lungs.
treated with Dasatinib may develop the PAH right after starting Sprycel or up to a year after treatment.
Symptoms of pulmonary hypertension often include shortness of breath, fatigue, and swelling of the body such as the ankles
and legs. Be sure to report anything you experience to your doctor. If you are concerned you are having
an allergic or other negative reaction to this medication, seek medical assistance
Indications: Dasatinib is an anti-cancer medication
that is best for treating metastatic melanoma and specific types of leukemia, and usually only in patients who
have either reacted badly to other leukemia treatments, or cannot use other treatments for other
rare cases Dasatinib can be used to treat certain specific noncancerous diseases, but this is uncommon and
should be thoroughly discussed with your doctor.
Dasatinib is available
in tablet form to be taken by mouth. This medication is usually taken once or twice daily at about the same
time each day, with or without food. The amount of active medicine in each tablet will vary, and it is
important to follow the directions of your doctor and on your prescription label as closely as you possibly
can. Depending on how you react to your medication, your doctor may either increase or decrease your dosage,
but this is nothing to be concerned about unless you are experiencing uncomfortable or dangerous side
stop talking this or any medication without first talking to your doctor, even if you are experiencing side
effects or, alternatively, you start to feel better.
Storage: keep Dasatinib tightly closed in the
container it came, out of the reach of
Dasatinib at room temperature (15-25 ° C), away from heat above 40 ° C, light and moisture. Dasatinib and all other
medications should not be used beyond the expiration date printed on the container.
drug can be fatal. The risk of complication is even higher when the drug is overdosed for a long term. In
fact, overdosing of certain chemotherapy drugs, including
Dasatinib, can lead to
death. Even in the absence of overdose,
Dasatinib can damage
the bone marrow. It is extremely important that you take the medication as indicated by your health care provider
or according to the directions on the label.
Missing dose: It is
important to take the
medication around the same time every day.
In case you forget to
take a dose, take the missed one as soon as you remember it. However, if it is almost time for your next
do not double the next dose to recover the missed one. Contact your doctor or wait to go back to your regular
: If you have ever had
liver disease, heart disease, other heart conditions, low levels of magnesium or potassium in the blood, or if
you have ever been lactose intolerant, you should report these things to your doctor before you begin taking
your medication. If you develop any of these conditions while on Dasatinib, contact your doctor as soon as
is contraindicated in case of:
to the drug or any of the constituents
Mechanism of action (MOA): Dasatinib is a protein-tyrosine kinase
inhibitor which kills cancer cells by blocking the protein kinases, proteins that are located within the
leukemic cells, and are responsible for their uncontrolled proliferation.
number of medications can have dire effects on patients who are taking Dasatinib. Several of these drugs, namely
those which fight blood breakdown through liver enzymes, and thicken your blood and cause many undesirable and
dangerous side effects (Sporanox, Biaxin, Reyataz, Crixivan, Viracept, Norvir, Invirase, Ketek, Vfend, and even
grapefruit juice are examples with this side effect). Some medications and even herbal supplements can make
Dasatinib ineffective by decreasing the concentration of Dasatinib in your system. Some medications that are
taken to reduce acid levels in the stomach can also reduce the amount of Dasatinib that is absorbed into your
system. Dasatinib can increase the side effects in the medication simvastatin and other medications that are
broken down in a similar way.
In addition to attacking cancer cells, Dasatinib may interfere with certain normal cells, and lead to the
development of side effects in some patients; most common Dasatinib side effects include:
loss of appetite
pain in the joint, hands or feet
mouth sores and/or swelling
nausea and vomiting
Stomach pain or swelling
the side effects above persist for weeks, contact your oncologist. In addition, contact your doctor if you
experience any of these symptoms:
- severe depression symptoms
infections: fever, sore throat, chills,...
sudden severe headache
swelling of the eyes, hands, arms, feet, or ankles
sudden weight gain
shortness of breath or difficulty breathing
coughing up bloody mucus
persistent chest pain or chest pressure
rapid or irregular heartbeat
unusual bruising or bleeding
black and tarry stools
blood in stools or urine
slow or difficult speech
Weakness or numbness of an arm or leg