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Cisplatin  (Platinol, Platinol®-AQ)   

Warnings: There are possible serious kidney problems and serious allergic reactions possible while using Cisplatin. Hearing loss (more common in children), bone marrow suppression, severe nausea and vomiting and bleeding problems may occur with this medication. The chances of these side effects increase with the dosage you are taking.

Talk to your doctor about any of these symptoms: trouble breathing, changes in the amount of your urine, swelling of the face, rashes, dizziness, ringing in the ears, easy bruising and bleeding, signs of infection, vomiting or nausea, unusual tired or weakness.

Indications: Cisplatin is a chemotherapy composed of platinum for the treatment of various types of cancer. It is meant to slow or stop the growth of certain types of cancer.

Cisplatin is used, most of the times, in association with other anticancer drugs, to treat the following cancers: 

  • multiple myeloma 
  • melanoma 
  • mesothelioma 
  • testicular cancer 
  • ovarian cancer 
  • bladder cancer 
  • head and neck cancer 
  • esophageal cancer 
  • small cell lung 
  • non small cell lung 
  • breast cancer 
  • cervical cancer 
  • stomach cancer 
  • Prostate cancer 
  • Hodgkin's lymphoma 
  • non-Hodgkin’s lymphoma 
  • Sarcomas 

Dosage:  This medication is intravenously given by a medical professional to the patient. The dosage that is given will depend on your body size, height and response to therapy. This medication should not be given more than once every 3 to 4 weeks.

Your doctor should intravenously give you more fluids while you are receiving this treatment. You should intake more fluids to reduce the risk of side effects from your kidneys. If you have any contact with the treatment, immediately wash your hands with soap and water.

Contraindications: Tell your doctor about any allergies you have, including to carboplatin which may make you have an allergic reaction. You should also tell your doctor if you have decreased bone marrow function, kidney disease, and loss of hearing and blood cell disorders. Tell your doctor all of your medical history including, numbing and tingling of the feet and hands, mineral imbalance, gout and kidney stones.  

You should consult your doctor before receiving any immunizations. Avoid people that have had recent oral polio vaccinations. Elderly people and children are more susceptible to the side effects, including hearing loss, tingling of the hands and feet and bleeding problems. Children are more susceptible to hearing loss than most.  

Pregnant women should not take this treatment as it can cause serious birth defects. It is known to pass through breast milk so women that have children should not breastfeed. Males also have their sperm affected by this medication so they should use birth control.   

Interactions: There are some medications that will interact with Cisplatin and cause harmful side effects. Amphotericin B, anti-seizure medications, aminoglycoside antibiotics, “water pills” (loop diuretics such as furosemide, bumetanide, ethacrynic acid), nalidixic acid pyridoxine when used in combination with both altretamine and Cisplatin can all have very harmful interactions. Consult with your doctor about all medications that you are taking.  

Side effects:  In addition to cancer cells, cisplatin also damage normal cells, which causes various side effects in most patients. The most common cisplatin side effects include:  

  • hair loss   
  • fatigue   
  • decreased appetite  
  • weight loss  
  • diarrhea or constipation  
  • nausea and vomiting  
  • changes in taste  
  • Numbness or tingling in the fingertips and toes.   

Cisplatin can cause serious side effects which require immediate medical attention; contact your doctor immediately if you experience any of these symptoms:     

 

  • high fever  
  • chills  
  • seizures   
  • severe depression 
  • shortness of breath  
  • breathing difficulty   
  • unusual bruising or bleeding  
  • dizziness or/and faintness  
  • pain in your side or back  
  • Swelling of your feet or ankles.   

 

References: 

1 -  ch.oddb.org, Information professionelle sur Cisplatin-Teva® 

2 - nlm.nih.gov, Cisplatin