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Carboplatin (Paraplatin )   

 

Warning: Carboplatin can cause various serious side effects that can seriously affect the health of a patient who is using it. When the medication is used over an extended period of time, it can cause certain blood disorders such as anemia and blood marrow suppression, which may result in infections or bleeding problems. The risk continues to increase with prolonged use and higher dosages. Traditionally, doctors will order various tests in order to monitor the number of blood cells in bone marrow so that any changes will be evident.

 

There is also a slight possibility of allergic reaction with this medication. Although uncommon, this reaction usually occurs within a few minutes of receiving the medication. All of the following side effects merit consultation with a medical professional: evidence of infection (fever, persistent sore throat), easy bruising/bleeding, unusual tiredness, rash, itching, swelling, severe dizziness, difficulty breathing.

Indication:  Carboplatin is a drug that is in liquid form and is in a class of drugs that are defined by the fact that they contain platinum. It is often used as part of chemotherapy treatment and can be administered alone or along with various other medications. It works to slow or to completely stop the reproduction of cancer cells in the body. One of the brand names for this medication is Paraplatin.

 

This drug is often used in the treatment of several types of cancer which include (but are not limited to) ovarian cancer, testicular cancer, cancer that affects the head and neck, bladder cancer, Wilms’ tumor, tumors in the brain, and retinoblastoma.

Dosage:  Like other medications that are used in chemotherapy, Carboplatin is generally administered and overseen by a medical professional. The intravenous injection usually takes at least fifteen minutes.

 

The dosage of this drug can vary from person to person and is affected by body type and size, as well as by the severity and the variety of the specific medical condition. While the amount given in a single dose may vary, it is not usually done more than once in a four week period, although this will be decided by the doctor

  

Overdose: the fact that  Carboplatin is administered in hospital, the risk of overdose is greatly reduced; however, it is not impossible. Carboplatin overdose increased the toxic effects of the medication, and cause severe headaches, malaise or life threatening conditions. If you suspect that you are overdosed, contact your health care provider or visit a drug and poison center  near immediately. Any negligence in chemotherapy overdose can lead to death.  

Contraindications: If you have a blood marrow or blood cell disorder, kidney problems or a mineral imbalance, consult with your doctor before taking this medication. In addition, carboplatin  is not indicated for patients who fall in the following conditions:  

  • pregnant women  
  • women who are breastfeeding   
  • allergy to carboplatin or its ingredients   
  • liver failure   
  • bleeding tumor 
  • History of severe allergy to mannitol.  

Interactions: There are several different medications that may interact with this drug in a variety of ways. That is why it is essential that you maintain a comprehensive list of the medications that you are taking and that you fully disclose this list to the doctor or pharmacist. Some of the medications that may interact with Carboplatin are amphotericin B, aminoglycoside antibiotics, certain diuretics, certain anti-seizure medications, and nalidixic acid.

Side effects: In addition to stopping the growth of cancer cells, Carboplatin may also interfere with your healthy cells that multiply quickly, and cause adverse effects. Common Carboplatin side effects include:

  • fatigue
  • sleepiness
  • hair loss
  • weight loss
  • ear ringing or hearing loss
  • nausea and vomiting
  • decreased appetite
  • taste changes
  • vision changes
  • numbness or tingling in the fingertips
  • bowel disorders (constipation or diarrhea)
  • Formation of sores in the mouth 

Although rare, Carboplatine can cause serious side effects which require immediate medical attention; contact your doctor immediately if you experience any of these symptoms:    

  • dizziness  
  • fainting (temporary loss of consciousness)  
  • shortness of breath or difficulty breathing  
  • high blood pressure
  • painful or difficulty swallowing  
  • yellowing of the skin or eyes (jaundice)   
  • unusual bruising or bleeding  
  • skin disorders such as rash, hives or itching  
  • Swelling of your arms, feet, ankles, or lower legs.   

 

References:  

 

1 - nlm.nih.gov,  Carboplatin