Trade name: Avastin
antibody" and "anti-angiogenesis
Availability: Avastin is available by prescription
Availability: Bevacizumab is available by
Indications: Bevacizumab is used to treat the
cancer – in the
treatment of metastatic colorectal cancer, Bevacizumab is usually given at the following doses: 5 mg/kg or
10 mg/kg body weight, administered once every 2 weeks; 7.5 mg/kg or 15 mg/kg administered once every 3
weeks through intravenous infusion.
Metastatic breast cancer
– to treat metastatic breast cancer, Bevacizumab is recommended at 10 mg / kg of body weight, administered once
every 2 weeks; or the dosage of 15 mg/kg body weight once every 3 weeks, given by infusion into a vein
Non-small cell Lung cancer (NSCLC)
– in the treatment of NSCLC, Bevacizumab is given in combination with a p
up to 6 cycles of treatment, followed by an Bevacizumab monochemotherapy ( Bevacizumab only) until remission. The
recommendation is 7.5 mg/kg or 15 mg/kg body weight given once every 3 weeks by intravenous
Advanced or metastatic kidney
cancer – if you
have an advanced kidney cancer, the dosage of Bevacizumab that your doctor can recommend is 10 mg/kg of body
weight, given once every 2 weeks by intravenous infusion.
Bevacizumab can be used to treat
age-related macular degeneration and other forms of cancers such as:
unresectable liver cancer
- metastatic or
unresectable locally advanced pancreatic cancer
- Glioblastoma multiforme (GBM), an
aggressive form of primary brain tumor.
Bevacizumab is given by
infusion into a vein (intravenous, IV)
Dosage: Bevacizumab should be administered by
professionals with the greatest care possible. It is recommended that the drug be given in hospital or health
care center equipped for its preparation. Bevacizumab is given by intravenous infusion every 14 days. In
general, the first dose is administered by intravenous infusion over 90 minutes. Depending on the reaction of
your body to the drug, the second infusion will last 60 minutes. If the second infusion is well tolerated by
your body, all subsequent infusions may be administered in 30 minutes.
body's reaction to the medication is not life threatening, dosage reduction is not recommended; the drug must be
taken as indicated. If life threatening reactions develop however, the treatment should be stopped permanently
the highest dose ever given to humans is 20 mg / kg of body weight every 2 weeks. In the majority of patients,
overdose causes severe migraine and other health problems. If you experience symptoms related to overdose during
the treatment, call your doctor or pharmacist right away.
if there are no major complications, treatment should not be interrupted. If for some reasons you will not be
present for the treatment, talk to your doctor in advance so that he can do the necessary. Misusing chemotherapy
drugs, including Bevacizumab,
can be nefast.
Bevacizumab is not recommended or should be used with precaution in the following circumstances:
who are pregnant or nursing
hepatic disease (liver disease)
to Bevacizumab or any of its ingredients
to products derived from chinese hamster ovary (CHO) cells or
cancer that has spread into the central nervous system.
Action (MOA): Bevacizumab
is an antineoplastic agent that works by preventing the production of blood vessels that nourish the cancer
cells, which may then inhibit the growth of the tumor.
combination of Bevacizumab with certain drugs can reduce its curative effect, and even cause health problems.
Therefore, before beginning the treatment, tell your doctor about prescription or/and nonprescription medications
you are taking. It is important to have the advice of your doctor before taking vitamins, nutritional supplements
and over-the-counter drugs.
Bevacizumab can bring good results in some cancer patients; however, it tends to cause adverse effects, which can
be serious. The most common Bevacizumab side effects include:
itching, or scaling of the skin
- Sores on
the skin or in the mouth.
serious side effects which require immediate medical attention; contact your doctor immediately if you
experience any of these symptoms:
- loss of
- black or
- slow or
or numbness of an arm or leg
faintness or confusion
gagging, or choking
headache (which can be a sign of overdose)
- Pain or
swelling of the face, eyes, stomach, hands, feet, ankles, or lower legs.