Brand name: Arimidex
Manufacturer / Distributor:
is available by prescription only
Indications: Anastrozole is used to treat breast
cancer in postmenopausal women, especially postmenopausal women in whom tamoxifen treatment is
doctor may use anastrozole to treat other medical conditions in addition to breast cancer. For instance, you can
be prescribed Anastrozole as preventive treatment if you are at risk for breast cancer.
Anastrozole comes in
tablet form to be taken by mouth, with or
Dosage: your doctor will determine the dose
that is most effective to treat your medical condition. In general, he will consider your weight, other medical
conditions you may have and other drugs you are taking. However, anastrozole is often recommended at a dose of 1
mg per day. Take the medication around the same time every day, with or without food. Even if you feel better,
it is important to take Anastrozole as recommended by your doctor or pharmacist. You may be recommended to take
Anastrozole for several years; usually 5 years.
Anastrozole can be taken with or without food, it is better to take anastrozole after a meal to reduce the risk
of nausea or vomiting.
is in pill form, overdose can occur during the treatment. In case you experience overdose symptoms, contact your
doctor or a local poison control center near you immediately. They will do what is necessary to eliminate or reduce
the symptoms, and avoid serious complications.
in case you
forget to take
Anastrozole at the
recommended time, take the missed dose as soon as you remember it if it is not almost time for the nest dose. In
case it is time for the next dose, do not double it to recover the missing, it can be dangerous. Contact your
doctor or wait to go back to your regular schedule.
is contraindicated, or should be used with precaution in the following conditions:
who are allergic to anastrozole or to one of its ingredients
beginning a treatment with Anastrozole, tell your
doctor if you have any of these health problems:
and galactose malabsorption / intolerance.
Mechanism of Action
Anastrozole works by
inactivating the action of aromatase, an enzyme necessary for the conversion of androgen into estrogen. Once
deactivated, aromatase is unable to provide estrogen to the growth and survival of breast cancer cells.
combination of Anastrozole with tamoxifen and all treatments containing estrogens is not recommended. These
substances can affect the action of Anastrozole in your body, and even cause serious health problems; talk to your
doctor before taking any of the following:
remedies , principally St. John Wort
espite the beneficial effects of the drug, Anastrozole tends to cause adverse effects in most patients.
Fortunately, these adverse effects tend to disappear when the body adjusts to the medication. The most common
Anastrozole side effects include:
- persistent or frequent
need to urinate
pain and heartburn
- difficulty falling or
disorders – constipation or diarrhea
bone, or muscle pain
changes or/and depression
of burning or tingling in your hands or feet.
cause serious side effects which require immediate medical attention; contact your doctor immediately if you
experience any of these symptoms:
swallowing or breathing
of the skin or eyes (Jaundice)
problems: ulcers, itching, rash, blisters, hives, etc.
problems such as bleeding, dryness or irritation
which can be accompanied with sore
throat and cough
of the eyes, face, lips, tongue, throat, arms, hands, feet, ankles, or lower legs.