Anticancer Properties of Kohlrabi
Kohlrabi is a
variety of cabbage. It is a veritable weapon against cancer, cardiovascular disease and neurodegenerative
disorders. As a nutritionist likes to say, “Kohlrabi deserves to be in every plate of people who want to become
or stay healthy.”
High in fiber,
this nutritious vegetable facilitates intestinal transit. Among other health elements it contains included
Sulforaphane, which has a destructive effect against H. Pylori bacteria present in the stomach and can lead to
ulcers and cancers. Sulforaphane, along with indoles, is also implicated in the destruction of cancerous cells
in the entire body.
epidemiological studies have shown high consumption of vegetables and fruit reduces the risk of cardiovascular
disease, some cancers, and other chronic medical conditions. It is believed the presence of antioxidants in
fruits and vegetables may play a role in this protection. But some plants are more powerful in fighting cancer
than others; kohlrabi is one of them.
have shown that regular consumption of kohlrabi, as well as other cruciferous vegetables (cabbage, cauliflower,
broccoli, Brussels sprouts...), may prevent certain cancers, such as lung, ovary and kidney. Although recent researches report that vegetables from the cruciferous family
have preventive effect on almost all cancers, current epidemiological evidence suggests they are mainly
effective in decreasing the risk of malignant tumor in the lung, prostate, breast, and the organs of the
Cancers of Prostate and Breast
In vitro studies
and in animals, it is shown that two active compounds in kohlrabi, the sulforaphane and indole-3-carbinol, could
prevent tumor formation, decrease the growth of cancer cells and promote their self-destruction. Although these
studies were mostly focus on cancer associated with hormone system (breast cancer, prostate cancer), other
results in animals also show a beneficial effect against cervical cancer.
In addition, it
was observed that sulforaphane in Kohlrabi has the ability to kill or reduce overgrowth of H. pylori, a
bacterium which can infect and cause stomach ulcer and cancer in humans. Further research is needed before
confirming these results in humans. Considering the currently available medical data, it appears that frequent
consumption of vegetables from the cruciferous family reduces the risk of metastasis in people who were
diagnosed with malignant tumor.
syndrome. Some people with irritable bowel syndrome may experience intolerance to crucifers, such as kohlrabi.
It is therefore important to limit the intake of the vegetable in case of abdominal pain, bloating, and/or
diarrhea. When the symptoms are mild or insignificant you can gradually reintegrate these foods, based on your
between cruciferous and certain medications. Indoles, compounds found naturally in cruciferous vegetables may
reduce in particular the action of some analgesics such as products containing acetaminophen (Tylenol®, Atasol®,
Tempra®) and other drugs like BENYLIN®, Contac®, and Robaxacet®.
1. Lampe JW. Health
effects of vegetables and fruit: assessing mechanisms of action in human experimental studies.
Am J Clin Nutr 1999 September;70(3 Suppl):475S-90S.
2. Brennan P, Hsu CC, et al. Effect
of cruciferous vegetables on lung cancer in patients stratified by genetic status: a mendelian randomisation
approach. Lancet 2005 October 29;366(9496):1558-60.
3. Hu J, Mao Y, White K. Diet
and vitamin or mineral supplements and risk of renal cell carcinoma in Canada. Cancer Causes Control 2003 October;14(8):705-14.
4. Pan SY, Ugnat AM, et al. A
case-control study of diet and the risk of ovarian cancer. Cancer
Epidemiol Biomarkers Prev 2004 September;13(9):1521-7.
5. Zhang Y. Cancer-preventive isothiocyanates:
measurement of human exposure and mechanism of action. Mutat
Res 2004 November 2;555(1-2):173-90.
6. Johnson IT. Glucosinolates: bioavailability
and importance to health. Int J Vitam Nutr Res 2002
7. Conaway CC, Yang YM, Chung FL. Isothiocyanates as cancer
chemopreventive agents: their biological activities and metabolism in rodents and humans.
Curr Drug Metab 2002 June;3(3):233-55.
8. Jeffery EH, Jarrell V. Cruciferous vegetables and cancer prevention.
In: Wildman REC, editor. Handbook of Nutraceuticals and Functional Foods.Boca Raton: CRC Press; 2001. p.
9. Hu R, Khor TO, et al. Cancer
chemoprevention of intestinal polyposis in ApcMin/+ mice by sulforaphane, a natural product derived from
cruciferous vegetable. Carcinogenesis 2006 May 4.
10. Hwang ES, Jeffery EH. Induction of quinone reductase by
sulforaphane and sulforaphane N-acetylcysteine conjugate in murine hepatoma cells. J Med Food 2005;8(2):198-203.
11. Myzak MC, Dashwood RH. Chemoprotection by sulforaphane:
keep one eye beyond Keap1. Cancer Lett 2006 February
12. Moreno DA, Carvajal M, et al. Chemical and biological
characterisation of nutraceutical compounds of broccoli. J Pharm
Biomed Anal 2006 May 17.
13. Brew CT, Aronchik I, et al. Indole-3-carbinol activates the
ATM signaling pathway independent of DNA damage to stabilize p53 and induce G1 arrest of human mammary
epithelial cells. Int J Cancer 2006 February
14. Firestone GL, Bjeldanes LF. Indole-3-carbinol and
3-3'-diindolylmethane antiproliferative signaling pathways control cell-cycle gene transcription in human breast
cancer cells by regulating promoter-Sp1 transcription factor interactions. J Nutr 2003 July;133(7 Suppl):2448S-55S.
15. Gong Y, Sohn H, et al. 3,3'-Diindolylmethane is a novel
mitochondrial H(+)-ATP synthase inhibitor that can induce p21(Cip1/Waf1) expression by induction of oxidative
stress in human breast cancer cells. Cancer Res 2006 May
16. Hsu JC, Zhang J, et al. Indole-3-carbinol inhibition of
androgen receptor expression and downregulation of androgen responsiveness in human prostate cancer
cells. Carcinogenesis 2005 November;26(11):1896-904.
17. Qi M, Anderson AE, et al. Indole-3-carbinol prevents PTEN
loss in cervical cancer in vivo. Mol Med 2005
18. Dashwood RH. Indole-3-carbinol: anticarcinogen
or tumor promoter in brassica vegetables?Chem Biol
Interact 1998 March 12;110(1-2):1-5.
19. Soerjomataram I, Oomen D, et al. Increased consumption of fruit and
vegetables and future cancer incidence in selected European countries. Eur J Cancer 2010;46:2563-80.
20. Harding AH, Wareham NJ, et al. Plasma
vitamin C level, fruit and vegetable consumption, and the risk of new-onset type 2 diabetes mellitus: the
European prospective investigation of cancer--Norfolk prospective study. Arch Intern Med 2008;168:1493-9.
21. Kim MK, Park JH. Conference on "Multidisciplinary approaches to nutritional problems". Symposium on "Nutrition
and health". Cruciferous vegetable intake and
the risk of human cancer: epidemiological evidence. Proc Nutr Soc 2009; 68: 103-110.
22. Herr I, Buchler MW. Dietary constituents of broccoli
and other cruciferous vegetables: implications for prevention and therapy of cancer. Cancer Treat Rev
2010; 36: 377-383.
23. Bosetti C,
Negri E, et al. A
pooled analysis of case-control studies of thyroid cancer. VII. Cruciferous and other vegetables
(International). Cancer Causes Control 2002
24. He FJ, Nowson CA, et al. Increased consumption of fruit and
vegetables is related to a reduced risk of coronary heart disease: meta-analysis of cohort
studies. J Hum Hypertens 2007;21:717-28.